Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research
نویسندگان
چکیده
منابع مشابه
Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research
Syndromes of accelerated aging could provide an entry point for identifying and dissecting the cellular pathways that are involved in the development of age-related pathologies in the general population. However, their usefulness for aging research has been controversial, as it has been argued that these diseases do not faithfully reflect the process of natural aging. Here we review recent find...
متن کاملProgeroid syndromes: probing the molecular basis of aging?
A valid method of studying age related degenerative pathologies is to study human genetic diseases that appear to accelerate many, though not necessarily all, features of the aging process. Such diseases are described as progeroid syndromes because of their possible relevance to many aspects of aging and age related disease. This article describes the recent progress made at the cellular and mo...
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Action research is a research methodology with a dual purpose (action and research). Action research as other research approach is led through a paradigm or a philosophical perspective. This article briefly describes paradigm, research paradigm and discuss about “which paradigm (positivism, interpretive, or praxis) does cover action research?”.
متن کاملBlocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.
Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the nuclear envelope, cause misshapen nuclei, and result in progeroid syndromes. A deficiency in ZMPSTE24, a protease involved in prelamin A processing, leads to prelamin A accumulation, an absence of mature lamin A, misshapen nuclei, and a lethal perinatal progeroid syndr...
متن کاملShared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging.
Segmental progeroid syndromes are those whose phenotypes resemble accelerated aging. Here we analyze those phenotypes and hypothesize that short telomeres produce the same group of symptoms in a variety of otherwise unrelated progeroid syndromes. Specific findings are the following: (a) short telomeres in some progeroid syndromes cause an alopecia/osteoporosis/fingernail-atrophy group of sympto...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2009
ISSN: 1537-744X
DOI: 10.1100/tsw.2009.159